Derivation of Convolution PK models
Convolution PK models are used for describing a complex absorption mechanism such as modal absorption curve like a camel with double peak. I could not find an explicit derivation how come C(t)=f(t)*i(t) becomes \displaystyle \frac{\partial C(t)}{\partial t}=f(t) - k C(t). Then, I summarized the basic concept behind it here. Let's make it clear.
Formula
The formula for the first derivative of convolution integral is: \begin{align} C(t)=f(t)*g(t)=\int_0^t f(\tau)g(t-\tau)d\tau \label{eq:con} \end{align}
\begin{align}
\frac{\partial C(t)}{\partial t}=\int_0^t f(\tau) \frac{\partial g(t-\tau)}{\partial t} d\tau + f(t)g(0)
\label{eq:der}
\end{align}
Let C(t) be concentration of central compartment at time t. One can consider that the function f(t) is PULSE INPUT, i.e., \displaystyle f(t)=\frac{d r(t)}{d t}, where r(t), 0 \le r(t) \le 1 is time-varying fraction of the dose released, and the function g(t) is fraction of remaining, i.e., \displaystyle g(t)=e^{-kt},0 \le g(t) \le 1, \Leftrightarrow \frac{d g(t)}{d t}=-k g(t). The part f(\tau)g(t-\tau) describes what amount of PULSE INPUT which occurred at time \tau will be still remaining at time t. Note that g(0)=e^{-k \cdot 0}=1.
Simple example for better understanding - 1
Consider which one has more impact on you at the moment, 1) Deadly accident in childhood, 2) Lost \$10 yesterday. In short, the function f and g are considered to be functions for the extent of impact and the rate of unforgetting, respectively.Simple example for better understanding - 2
For example, suppose the function g(t)=1, where no elimination is assumed, then Eq.(\ref{eq:con}) becomes C(t)=\int_0^t f(\tau)d\tau=r(t)-r(0)=r(t), since the fraction of dose at time 0 should be 0.Conclusion
Then Eq.(\ref{eq:der}) can be \begin{align} \frac{\partial C(t)}{\partial t} &=\int_0^t f(\tau) \frac{\partial e^{-k(t-\tau)}}{\partial t} d\tau + f(t)e^{-k0} \nonumber \\ &= -k\int_0^t f(\tau) e^{-k(t-\tau)} d\tau + f(t) \nonumber \\ &= -k\int_0^t f(\tau) g(t-\tau) d\tau + f(t) \nonumber \\ &= f(t) - k C(t) \label{eq:sol} \end{align}
The function f(t) corresponds to the part of k_a C_{abs}(t) in a conventional model.
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